What should be the focus of my thesis statement about "Wise Blood"? Would a thesis focusing on irony be effective for "Wise Blood"?

Your thesis statement may very well concern irony, however
it should also illuminate a significant aspect of the work you are discussing.  Ideally,
your thesis would explain both how irony is used within the story and what purpose/what
effect this irony has.  As you are writing your essay, you would explain upon how irony
is used primarily by citing examples within the story of moments of irony and then to
answer the second part, perform a close reading of the examples you have chosen and
relate them to the work as a whole.

Be sure to also draw
distinctions between the different types of irony or to clarify which kind of irony you
are focusing on.